What is hyaluronidase?

what is hyaluronidase

What is Hyaluronidase?

Hyaluronidase is a solution used for patients with prominent visual defects caused by the incorrect application of hyaluronic acid-based dermal fillers, especially in the lips. It is considered one of the most effective medical treatments for addressing these blemishes.

What is Hyaluronic Acid and Hyaluronidase?

Hyaluronic acid is a natural carbohydrate found in the skin of all humans. Its primary function is to attract water and keep the skin healthy. While it is predominantly present in the skin, hyaluronic acid is also found in the eyeballs, skeleton, and blood vessels.

To dissolve a hyaluronic acid-based dermal filler, a special enzyme called hyaluronidase is injected under the skin. Hyaluronidase is an enzyme that breaks down hyaluronic acid. The human body contains six different types of hyaluronidase enzyme.

How is the Procedure Carried Out?

The hyaluronidase injection is administered subcutaneously at the site of the previously injected dermal filler. The results are visible almost immediately, but the final dissolution of the filler typically takes place within one week after the treatment. In some cases, a second hyaluronidase injection may be required. Importantly, this procedure does not necessitate any recovery period.

Positive Effects of Hyaluronidase

1. **Swift Resolution:** One of the key benefits of hyaluronidase is its rapid action. It can effectively dissolve hyaluronic acid fillers, providing quick relief for patients who are dissatisfied with their filler results.

2. **Versatility:** Hyaluronidase is versatile and can be used to correct various issues resulting from dermal filler injections, such as overfilled lips or uneven distribution of filler.

3. **Non-Surgical:** Unlike many corrective procedures, hyaluronidase injections are non-surgical and do not require extensive downtime.

Negative Side Effects of Hyaluronidase

1. **Allergic Reactions:** In rare cases, individuals may experience allergic reactions to hyaluronidase, resulting in redness, itching, or swelling at the injection site.

2. **Temporary Bruising:** Some patients may experience temporary bruising or swelling at the injection site, which usually resolves within a few days.

3. **Over-Correction:** Inexperienced or unskilled administration of hyaluronidase can lead to over-correction, causing unintended aesthetic changes that may require further correction.


Hyaluronidase is a valuable tool for addressing issues related to hyaluronic acid-based dermal fillers. While it offers rapid resolution of filler problems and is generally safe, it is essential to consult with a qualified healthcare professional before undergoing the procedure. They can assess your specific needs, provide expert advice, and ensure the best possible outcome.

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